How CCAN contributes to chromosome segregation

Lakxmi Subramanian (primary)
School of Biological & Chemical Sciences
Queen Mary University of London
Viji Draviam (secondary)
School of Biological & Chemical Sciences
Queen Mary University of London

Abstract

Centromeres are the unique loci on eukaryotic chromosomes that ensure accurate chromosome segregation during cell division, by facilitating the assembly of large multi-protein complexes known as kinetochores. Centromeres and kinetochores are conserved throughout eukaryotes. The >100 proteins and protein complexes that constitute them are also largely conserved. However, the mechanisms by which each of these proteins and protein sub-complexes contribute to chromosome segregation are not well understood. This project will use cutting edge state-of-the-art genome-wide, proteome-wide and high-resolution imaging techniques to dissect how the CCAN network of proteins contribute to chromosome segregation in evolutionarily distant fission yeast and human cells.


References

1. Musacchio & Desai Biology 2017
2. Drinnenberg Trends in Cell Biol
3. McAinsh EMBO J 2006
4. Subramanian Open biol 2014
5. Shreshtha Nat Comm 2017


BBSRC Area
Molecules, cells and industrial biotechnology
Area of Biology
Cell BiologyGenetics
Techniques & Approaches
BiochemistryBioinformaticsGeneticsMathematics / StatisticsMicroscopy / ElectrophysiologyMolecular Biology