Genomes vary widely between species. For example, the number of genes, genome length, and repetitive sequence elements. Chromosome structure and number also vary widely, even between species with similar genome sizes. We and others have recently shown that in humans, specific chromosome features (such as chromosome size, centromere length and composition) can predispose to instability of specific chromosomes during cell division. Our aim is to understand how chromosome biology impacts genome stability, not only in humans, but across life. To do this we will combine cell biological studies and bioinformatic analysis of multiple species, to identify mechanisms that control chromosome stability.
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