Cancer research has recently benefitted from the integration of evolutionary mathematical theory to study somatic genome evolution during tumour development. We have recently shown that in humans, specific chromosome features (such as chromosome size, centromere length and composition) can predispose to instability of specific chromosomes during cell division. Our aim is to understand how chromosome biology across species impacts genome stability, and the likelihood of developing cancer.
Using both experimental and computational biology and analysis of human and animal genomes, this PhD project will investigate mechanistic principles of chromosomal instability during both species and somatic evolution.
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