Parvalbumin (PV)-positive interneurons, one of the most important interneuron subtypes in the cerebral cortex, only express their identifying protein marker at early postnatal stages, after critical periods of circuit formation. In order to modulate their function, and understand neurodevelopmental disorders associated with defects in these cells, it is necessary to find an early marker for them. We will perform single-cell genomic analysis on early and maturing interneuron progenitors, followed by bioinformatic analysis and in vivo expression studies, in order to identify potential markers of this cell type during critical periods of brain development.
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