Imaging and selective stimulation of fascicles in the cervical vagus nerve using fast neural Electrical Impedance Tomography and new flexible penetrating electrodes

Prof David Holder (primary)
Medical Physics
UCL
Mr Justin Perkins (secondary)
Equine Surgery
Royal Vet College

Abstract

There is great current interest in treating conditions such as epilepsy or arthritis by electrical stimulation of nerves in the body. Unfortunately, this will be limited if there is inadvertent stimulation of nerve fibres leading to organs besides those necessary. We propose development of a new electrode cuff “cartwheel” design that will enable detailed imaging and then selective stimulation of the correct fibres, using the new medical imaging method of fast neural Electrical Impedance Tomography. We seek to improve the spatial resolution and penetration depth of electrical impedance tomography (EIT) using a customizable electrode size, geometry, charge injection and placement.


References

Aristovich, K. Y., Packham, B. C., Koo, H., dos Santos, G. S., McEvoy, A., & Holder, D. S. (2016). Imaging fast electrical activity in the brain with electrical impedance tomography. NEUROIMAGE, 124, 204-213. doi:10.1016/j.neuroimage.2015.08.071
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Kirill Aristovich, Matteo Donega, Justin Perkins, Catherine Fjordbakk, James Avery, and David Holder (2017). In-vivo EIT imaging of spontaneous phasic activity in peripheral nerves. 18th International Conference on Biomedical Applications of Electrical Impedance Tomography (EIT2017), Thayer School of Engineering at Dartmouth, Hanover, New Hampshire, USA, 21-24 June, 2017. DOI: 10.5281/zenodo.557093,37.
Kirill Aristovich, Matteo Donega, Justin Perkins, Catherine Fjordbakk, James Avery, and David Holder (2017). In-vivo EIT imaging of spontaneous phasic activity in peripheral nerves. 18th International Conference on Biomedical Applications of Electrical Impedance Tomography (EIT2017), Thayer School of Engineering at Dartmouth, Hanover, New Hampshire, USA, 21-24 June, 2017. DOI: 10.5281/zenodo.557093,37.
1Karbiener, M., Jarvis, J.C., Perkins, J.D., Lanmüller, H., Schmoll, M., Rode, H.S., Gerstenberger, C. and
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BBSRC Area
Animal disease, health and welfare
Area of Biology
NeurobiologyPhysiology
Techniques & Approaches
BiophysicsEngineeringMathematics / StatisticsMicroscopy / Electrophysiology