Imaging immune-tumour interactions in cancer for uncovering novel strategies to improve the efficacy of immunotherapies

James Arnold (primary)
Cancer and Pharmaceutical Sciences
King's College London
Simon Ameer-Beg (secondary)
Cancer and Pharmaceutical Sciences
King's College London


Immune checkpoint therapies such as anti-PD-1 and -CTLA-4 have resulted in unprecedented responses, even cures, for some patients with late-stage cancer. However, the majority of patients fail to respond to such therapies. This study will focus on utilising cutting-edge imaging techniques to study the T cell-tumour cell interaction in vitro and in vivo using models of cancer to further understand how T-cells target and kill tumour cells. The aim is to identify and explore novel therapeutic opportunities to improve the efficacy of anti-tumour immune responses.


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Molecules, cells and industrial biotechnology
Area of Biology
Cell BiologyImmunology
Techniques & Approaches
BiochemistryBiophysicsImage ProcessingMicroscopy / ElectrophysiologyMolecular Biology