Imaging receptor signaling in cancer

Stephanie Kermorgant (primary)
Barts Cancer Institute
Paul Fromme (secondary)
Department of Mechanical Engineering


Receptor tyrosine kinases (RTK), playing major role in physiology and cancer, transmit information not only from the cell surface but also from inside the cells, on endosomes. Endosomes influence the intensity and the duration of the signaling. The aim is to generate methods to assess the RTK signaling spatially. This project will apply engineering technology for the automatic imaging, quantification, and modeling of RTK “endosomal signaling” in human cancer cells’ spheroids and tissues, combined to biochemistry and invasion-growth’s assays. Novel technologies measuring and modeling receptor endosomal signaling will be generated, enhancing knowledge of receptor signaling and influence on cell behavior.


1 Joffre C, Barrow R, Ménard L, Calleja V, Hart IR and Kermorgant S. A direct role for Met endocytosis in tumorigenesis Nature Cell Biology 13:827-37
2 Barrow-McGee R, Kermorgant S. Met Endosomal Signalling: In the right place, at the right time. Int J Biochem Cell Biol 2014, 49:69-74;
3 Ménard L, Parker PJ, Kermorgant S. Receptor Tyrosine Kinase c-Met controls the cytoskeleton from different endosomes via different pathways. Nature Communications 2014, 5:3907
4 Barrow-McGee, R. et al. Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes. Nature Communications 2016, 7:11942
5 Hervieu A, Farrah Heuss S, Zhang C, Barrow-McGee R, Joffre C, Ménard L, Clarke PE, Kermorgant S. API3K- and GTPase-independent Rac1–mTOR mechanism mediates MET-driven anchorage-independent cell growth but not migration. Science Signalling 2020 13, eaba8627.

Molecules, cells and industrial biotechnology
Area of Biology
AgeingCell Biology
Techniques & Approaches
BiochemistryEngineeringImage ProcessingMathematics / StatisticsMicroscopy / ElectrophysiologyMolecular BiologySimulation / Modelling