Incorporating the Circadian Clock into Induced Pluripotent Stem Cell model systems

David Lee (primary)
School of Engineering & Materials Science
Queen Mary University of London
Alexey Zaikin (secondary)
Department of Mathematics
University College London


There is increasing interest in the use of induced pluripotent stem (IPS) cells in predictive laboratory models for drug discovery and other applications. Physiological processes are co-ordinated by circadian clocks, that endow tissues with endogenous oscillations in gene expression and activity with a period of ~24hr. Circadian rhythms in our bodies are controlled by a range of chemical and mechanical environmental timing cues, however cells in laboratory culture typically do not exhibit a circadian rhythm. This project aims to develop IPS-derived cell models that incorporate the circadian clock, making them closer to tissue in our bodies.


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Genes, development and STEM* approaches to biology
Area of Biology
Cell BiologyPhysiology
Techniques & Approaches
BiochemistryBiophysicsMathematics / StatisticsMicroscopy / ElectrophysiologyMolecular BiologySimulation / Modelling