Abstract
There is increasing interest in the use of induced pluripotent stem (IPS) cells in predictive laboratory models for drug discovery and other applications. Physiological processes are co-ordinated by circadian clocks, that endow tissues with endogenous oscillations in gene expression and activity with a period of ~24hr. Circadian rhythms in our bodies are controlled by a range of chemical and mechanical environmental timing cues, however cells in laboratory culture typically do not exhibit a circadian rhythm. This project aims to develop IPS-derived cell models that incorporate the circadian clock, making them closer to tissue in our bodies.
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