Abstract
Dietary nutrients and microbial components are known to affect metabolic health over the life course. Saturated fatty acids and bacterial endotoxins affect the cells of the immune system and metabolic tissues alike. These molecules are known to cause adverse metabolic effects through activation of inflammatory pathways. Developments in mass spectrometry-based proteomics provide a so far unexploited opportunity to identify signalling pathways activated by metabolic stressors. These pathways can potentially be targeted pharmacologically in the prevention or therapy of age-related metabolic diseases.
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