Abstract
Zoonotic diseases pose a serious risk to human/animal health and welfare, with global socioeconomic consequences (as emphasised by recent events). Avian influenza and Campylobacter are key zoonoses, affecting humans and poultry. Multiple control strategies have been implemented, with limited success. Here, we will use a holistic one-health approach to study the genetics underlying pathogen resistance in humans and animals, moderated by their microbiomes and environments. We will implement advanced mathematical modeling to generate new epidemiological knowledge and cutting–edge “omics” technologies that could provide new insights to host-pathogen-microbiome interactions driving disease perturbation, working towards novel approaches to control zoonoses.
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