Lameness is a debilitating and painful condition, compromising considerably animal and human welfare. In dairy-cattle, lameness affects one third of animals with the main cause being the claw horn disruption lesions (CHDL). Our initial genetic studies showed that the disease is heritable. Further “-omics” studies could provide new insights to mechanisms driving disease perturbation and facilitate disease control through breeding-programmes, novel DNA-tests and novel drug- and vaccine-target discovery. We will integrate genomics/transcriptomics/proteomics/epigenetics and applied cutting edge machine-learning and systems-biology approaches to investigate the genetic architecture and the underlying molecular mechanisms of CHDL in order to develop new tools to control the disease.
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