Interaction of bacterial metabolites and nutrients in regulation of enteric and autonomic nervous system function in health.

Qasim Aziz (primary)
Centre for Neuroscience, Surgery and Trauma
Barts and The London School of Medicine and Dentistry, Queen Mary University of London UK
Andrea Malaspina (secondary)
Department of Neuromuscular Diseases
Faculty of Brain Sciences, Queens Square Institute of Neurology, University College London


While the connection between food intake, microbial profile and gut health is known, the molecular mechanisms underlying this interaction are poorly understood. It appears likely that gut health, as well as brain health are intricately linked via neuronal pathways at the level of the gut, i.e. the enteric nervous system (ENS), as well as through central connections mediated by the vagus nerve and autonomic nervous system. The aim of this project is understand how bacterial metabolites and nutrients regulate neuronal pathways within the gut wall and then translate these findings into clinical studies where autonomic function and gut physiology will be studied in healthy subjects.


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Plants, microbes, food and sustainability
Area of Biology
Cell BiologyGeneticsImmunologyMicrobiologyNeurobiologyPhysiology
Techniques & Approaches
GeneticsMicroscopy / ElectrophysiologyMolecular Biology