While the connection between food intake, microbial profile and gut health is known, the molecular mechanisms underlying this interaction are poorly understood. It appears likely that gut health, as well as brain health are intricately linked via neuronal pathways at the level of the gut, i.e. the enteric nervous system (ENS), as well as through central connections mediated by the vagus nerve and autonomic nervous system. The aim of this project is understand how bacterial metabolites and nutrients regulate neuronal pathways within the gut wall and then translate these findings into clinical studies where autonomic function and gut physiology will be studied in healthy subjects.
Symonds, Peiris et al, Mechanisms of activation of mouse and human enteroendocrine cells by nutrients, Gut. 64(4):618-26, 2015.
Peiris et al, A decoy bypass for appetite suppression in obese adults: role of synergistic nutrient sensing receptors GPR84 and FFAR4 on colonic endocrine cells, Gut. In Press.
Peiris et al, Human visceral afferent recordings: Preliminary Report, Gut. 60(2):204-8, 2011.
Aktar et al, The extracellular matrix glycoprotein Tenascin-X regulates peripheral sensory and motor neurons, J Physiol. Sep;596(17):4237-4251, 2018.
Van Oudenhove L. et al. Fatty acid–induced gut-brain signaling attenuates neural and behavioral effects of sad emotion in humans. J Clin Invest. Aug;121(8):3094-9, 2011