Intervention of innate immunity suppression caused by bacterial ubiquitin ligases in crops

Benjamin Stieglitz (primary)
Department of Biochemistry, School of Biological and Chemical Sciences
Queen Mary University of London
Guy Hanke (secondary)
Department of Biochemistry, School of Biological and Chemical Sciences
Queen Mary University of London


In the fight against microbial infection the posttranslational modification of proteins with ubiquitin is used to transduce signals required for an innate immune response. Pathogens have developed strategies to evade this host defense mechanism by subverting the ubiquitylation machinery. This project aims to understand how effectors from Gram-negative bacteria manipulate ubiquitin conjugation pathways to undermine pattern-triggered immunity in plants. This knowledge will be used to develop together with our industrial partner a novel crop protection agent. The project requires an interdisciplinary approach using techniques from different branches like structural biology, physical biochemistry, chemical biology, molecular cloning, microbiology and plant genetics.


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Molecules, cells and industrial biotechnology
Area of Biology
BiotechnologyStructural Biology
Techniques & Approaches
BiochemistryBiophysicsGeneticsMolecular BiologySimulation / Modelling