In the fight against microbial infection the posttranslational modification of proteins with ubiquitin is used to transduce signals required for an innate immune response. Pathogens have developed strategies to evade this host defense mechanism by subverting the ubiquitylation machinery. This project aims to understand how effectors from Gram-negative bacteria manipulate ubiquitin conjugation pathways to undermine pattern-triggered immunity in plants. This knowledge will be used to develop together with our industrial partner a novel crop protection agent. The project requires an interdisciplinary approach using techniques from different branches like structural biology, physical biochemistry, chemical biology, molecular cloning, microbiology and plant genetics.
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