Abstract
Three RNA polymerases transcribe the eukaryotic nuclear genome: Pol I, II and III. Historical bias has favoured the study of Pol II since it transcribes coding, messenger RNAs. The host lab has initiated the investigation of Pol III function in the adult fruit fly. Previous PhD student has shown that inhibition of Pol III, a key enzyme in generating protein translation machinery, extends lifespan downstream of an important nutrient-signalling pathway. This project will examine the long-term memory of inhibiting the production of protein synthesis machinery. It is focused on the biology of ageing due to the urgent need to understand ageing for treatment of age-related diseases that cause the biggest burden in contemporary societies.
References
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