Investigating biomechanical stimulation of the perisoteal stem cell niche towards developing regenerative medicine strategies for bone loss

Malcolm Logan (primary)
Randall Centre for Cell and Molecular Biophysics
King's College London
Andrew Pitsillides (secondary)
Comparative Biomedical Sciences
Royal Veterinary College


The skeleton is remodelled throughout life with older tissue being replaced by new cells. This constant turnover enables bone to respond to exercise and increase in size and density, while under reduced load bone mass is lost. Imbalance in the turnover of bone is the basis of diseases such as osteoporosis.

The periosteum, a thin layer of cells surrounding the outer surface of bone, is one source of tissue-resident stem cells that generates bone progenitors during bone homeostasis. The mechanisms by which periosteal cells respond to biomechanical stimuli is not known, nor is it understood why this declines with age.


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Genes, development and STEM* approaches to biology
Area of Biology
Techniques & Approaches
BiophysicsImage ProcessingMicroscopy / ElectrophysiologySimulation / Modelling