Investigating how migrating cells change their metabolism in response to mechanical signals.

Victoria Sanz Moreno (primary)
Barts Cancer Institute
Queen Mary University of London
Maria R (Sasi) Conte (secondary)
Randall Centre for Cell and Molecular Biophysics
King's College London

Abstract

Migration and invasion are key events during immune responses, wound healing and metastatic dissemination. Physical interactions between cancer cells and the surrounding extracellular matrix (ECM) guide such processes. Moving cells sense and translate physical clues into intracellular signals, which trigger metabolic reprogramming and changes in gene expression. These adaptations enable cells to migrate and invade tissues: however, the link between ECM mechanics and metabolism/energetics of migrating cells remains to be determined.


References

1.Georgouli M, Herraiz C, Crosas-Molist E, Fanshawe B, Maiques O, Perdrix A, Pandya P, Cantelli G, Rodriguez-Hernandez I, Karagiannis P, Lam H, Josephs D, Matias-Guiu X, Marti RM, Nestle FO, Orgaz JL, Malanchi I, Fruhwirth GO, Karagiannis SN and Sanz-Moreno V (2019) Regional activation of Myosin II in cancer cells drives tumour progression via a secretory cross-talk with the immune microenvironment. Cell. doi: 10.1016/j.cell.2018.12.038.
2.Herraiz C, Calvo F, Pandya P, Cantelli G, Rodriguez-Hernandez I, Orgaz JL, Kang N, Chu T, Sahai E and Sanz-Moreno V (2016) Reactivation of p53 by a cytoskeletal sensor to control the balance between DNA damage and tumor dissemination. J Natl Cancer Inst. 13;108 (1). doi: 10.1093/jnci/djv289.
3.Cantelli G, Orgaz JL, Rodriguez-Hernandez I, Karagiannis P, Maiques O, Matias-Guiu X, Nestle FO, Marti RM, Karagiannis SN and Sanz-Moreno V (2015) TGFbeta-induced transcription sustains amoeboid melanoma migration and dissemination. Curr Biol, 16;25(22):2899-914. doi:10.1016/j.cub.2015.09.054.
4.Orgaz JL, Pandya P, Dalmeida R, Karagiannis P, Sanchez-Laorden B, Viros A, Albrengues J,Nestle FO, Ridley AJ, Gaggioli C, Marais R, Karagiannis SN and Sanz-Moreno V (2014). Diverse Matrix metalloproteinase functions regulate cancer amoeboid migration. Nat Comm, doi:10.1038/ncomms5255
5.Markley JL, Br├╝schweiler R, Edison AS, Eghbalnia HR, Powers R, Raftery D, Wishart DS (2017) The future of NMR-based metabolomics. Curr Opin Biotechnol. 43:34-40. doi: 10.1016/j.copbio.2016.08.001


BBSRC Area
Molecules, cells and industrial biotechnology
Area of Biology
Cell BiologyChemical Biology
Techniques & Approaches
BiochemistryBioinformaticsBiophysicsImage ProcessingMicroscopy / ElectrophysiologyMolecular Biology