Investigating how migrating cells change their metabolism in response to mechanical signals.

Victoria Sanz Moreno (primary)
Barts Cancer Institute
Queen Mary University of London
Maria R (Sasi) Conte (secondary)
Randall Centre for Cell and Molecular Biophysics
King's College London


Migration and invasion are key events during immune responses, wound healing and metastatic dissemination. Physical interactions between cancer cells and the surrounding extracellular matrix (ECM) guide such processes. Moving cells sense and translate physical clues into intracellular signals, which trigger metabolic reprogramming and changes in gene expression. These adaptations enable cells to migrate and invade tissues: however, the link between ECM mechanics and metabolism/energetics of migrating cells remains to be determined.


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Molecules, cells and industrial biotechnology
Area of Biology
Cell BiologyChemical Biology
Techniques & Approaches
BiochemistryBioinformaticsBiophysicsImage ProcessingMicroscopy / ElectrophysiologyMolecular Biology