Investigating the cellular mechanisms of skeletal muscle regeneration using in vitro and experimental-data-driven computational modelling

Ryo Torii (primary)
Department of Mechanical Engineering
University College London
Darren Player (secondary)
Division of Surgery and Interventional Science
University College London


The cellular mechanisms of muscle regeneration are complex and are thought to play a role in muscle (mal)adaptation in health and disease. The process of regeneration is controlled by many factors, e.g. resident stem cells, nutrient and growth factor supply and external mechanical stimuli. The project aim is to investigate contribution of these factors, using in vitro and ex vivo (histology) data, incorporated in a multi-scale computational model. The study will entail better understanding and eventually optimisation of the regeneration process, which has a vast variety of applications such as accelerated muscle regeneration and development of efficient drug testing environments.


Jones, J.M., Player, D.J., Martin, N.R.W., Capel, A.J., Lewis, M.P., Mudera, V., (2018), An Assessment of Myotube Morphology, Matrix Deformation, and Myogenic mRNA Expression in Custom-Built and Commercially Available Engineered Muscle Chamber Configurations. Frontiers in Physiology, 9, DOI: 10.3389/fphys.2018.00483.

Torii, R., Velliou, R. I., Hodgson, D. and Mudera, V. (2018) Modelling multi-scale cell-tissue interaction of tissue-engineered muscle constructs. Journal of Tissue Engineering, Under review (minor revision after 1st round)

Vavourakis V, Eiben B, Hipwell JH, Williams NR, Keshtgar M and Hawkes DJ. Multiscale Mechano-Biological Finite Element Modelling of Oncoplastic Breast Surgery-Numerical Study towards Surgical Planning and Cosmetic Outcome Prediction. PLoS One. 2016; 11: e0159766.

Genes, development and STEM* approaches to biology
Area of Biology
Techniques & Approaches
EngineeringImage ProcessingMicroscopy / ElectrophysiologySimulation / Modelling