Investigating the diseased extracellular matrix in fibrotic scars

Brian Stramer (primary)
Randall Centre for Cell and Molecular Biophysics
King's College London
Tanya Shaw (secondary)
Kings College London


Keloids are a pathological healing response that result in scars that overgrow the boundary of the initial wound area with no known cause or cure. Our lack of understanding is due to an insufficient framework to study this phenomenon; there is no animal model that mimics the disease and research relies on primary clinical samples from individual patients, which slows the pace of research. This project aims to develop an in vitro model of scarring, characterising the altered composition and mechanics of the extracellular matrix, in order to elucidate causes of and treatments for the disease.


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Animal disease, health and welfareGenes, development and STEM* approaches to biology
Area of Biology
Cell Biology
Techniques & Approaches
BiochemistryBiophysicsImage ProcessingMicroscopy / Electrophysiology