Insecticide resistance is now a pervasive global phenomenon affecting two-thirds of countries with ongoing malaria transmission. The severity of this threat is currently unknown because there is limited evidence linking the operational failure of vector control interventions to the presence of local, resistant mosquito species. This PhD project will employ a next generation sequencing to characterize the mechanisms driving insecticide resistance among major mosquito vector species in Tanzania and Benin, identify resistance markers and design mathematical models for field surveillance and resistance management, and investigate the impact insecticide resistance has on malaria transmission dynamics, including mosquito fitness and vector-parasite interactions.
Protopopoff N, Mosha JF, Lukole E, Charlwood JD, Wright A, Mwalimu CD, Manjurano A, Mosha FW, Kisinza W, Kleinschmidt I, Rowland M. Effectiveness of a long-lasting piperonyl butoxide-treated insecticidal net and indoor residual spray interventions, separately and together, against malaria transmitted by pyrethroid-resistant mosquitoes: a cluster, randomized controlled, two-by-two factorial design trial. Lancet. 2018 Apr 21;391(10130):1577-1588.
Stica C, Jeffries CL, Irish SR, Barry Y, Camara D, Yansane I, Kristan M, Walker T, Messenger LA. Characterizing the molecular and metabolic mechanisms of insecticide resistance in Anopheles gambiae s.l. in Faranah Guinea. bioRxiv 610998; doi: https://doi.org/10.1101/610998
Collins E, Vaselli NM, Sylla M, Beavogui AH, Orsborne J, Walker T, Messenger LA. Investigating the relationship between insecticide resistance, underlying molecular mechanisms and malaria prevalence in Anopheles gambiae s.l. from Guinea. bioRxiv 434688; doi: https://doi.org/10.1101/434688. Scientific Reports Accepted.
Sherrard-Smith E, Griffin JT, Winskill P, Corbel V, Pennetier C, Djénontin A, Moore S, Richardson JH, Müller P, Edi C, Protopopoff N, Oxborough R, Agossa F, N’Guessan R, Rowland M, Churcher TS. Systematic review of indoor residual spray efficacy and effectiveness against Plasmodium falciparum in Africa. Nat Commun. 2018 Nov 26;9(1):4982.
Dagg K, Irish S, Wiegand RE, Shililu J, Yewhalaw D, Messenger LA. Evaluation of toxicity of clothiandin (neonicitinoid) and chlorfenapyr (pyrrole) insecticides and cross-resistance to other public health insecticides in Anopheles arabienesis from Ethiopia. Malar J. 2019 Feb 22;18(1):49.