Abstract
Insecticide resistance is now a pervasive global phenomenon affecting two-thirds of countries with ongoing malaria transmission. The severity of this threat is currently unknown because there is limited evidence linking the operational failure of vector control interventions to the presence of local, resistant mosquito species. This PhD project will employ a next generation sequencing to characterize the mechanisms driving insecticide resistance among major mosquito vector species in Tanzania and Benin, identify resistance markers and design mathematical models for field surveillance and resistance management, and investigate the impact insecticide resistance has on malaria transmission dynamics, including mosquito fitness and vector-parasite interactions.
References
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