The placenta plays a critical role in controlling the exchange of nutrients and metabolites between mother and fetus. While it is shared between them, it is primarily regulated by the fetal (epi)genome, suggesting that placental epigenetic marks could be important determinants of fetal growth and infant development. This study will analyse a large multi-omic dataset from a unique mother-infant cohort in rural Gambia comprising whole placental DNA methylome and genome data, and multiple outcomes including measures of fetal and infant growth, cognitive function and neural connectivity measured by functional near infrared spectroscopy.
1 Lester, B. M. & Marsit, C. J. Epigenetic mechanisms in the placenta related to infant neurodevelopment. Epigenomics 10, 321–333 (2018).
2 Lloyd-Fox, S. et al. Habituation and novelty detection fNIRS brain responses in 5- and 8-month-old infants: The Gambia and UK. Developmental Science 22, e12817 (2019).
3 Kessler, N. J., Waterland, R. A., Prentice, A. M. & Silver, M. J. Establishment of environmentally sensitive DNA methylation states in the very early human embryo. Sci. Adv. 4, eaat2624 (2018).
4 Xu, L. & Seki, M. Recent advances in the detection of base modifications using the Nanopore sequencer. Journal of Human Genetics 65, 25–33 (2020).
5 James P, Silver M, Prentice A. Epigenetics, nutrition and human health. Sight and Life. 2015; 29(1):35-38.