Abstract
During development, tissue morphogenetic movement can occur within the deforming tissue autonomously or in response to mechanical forces exerted by other parts of the embryo. However, separating the relative contribution of induced-morphogenesis from tissue-autonomous morphogenesis during development remains challenging. We will examine this in the enveloping layer (EVL), a simple squamous epithelium that enwraps embryonic tissues in zebrafish. We will investigate how EVL cells respond to morphogenetic changes in the underlying tissues, examine tissue-scale mechanical forces by manipulating shapes of the underlying tissues or by modulating the intrinsic property of EVL cells, in combination with computational modelling of this process.
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