Maintaining redox homeostasis is crucial for cell viability. It has recently been discovered that coenzyme A (CoA) acts as an essential antioxidant, protecting cells against oxidative stress and iron-induced cell death (ferroptosis). These effects are mediated through CoA-dependent regulation of peroxiredoxin-6 (CoAlation). However, it remains unknown exactly how PRDX6 CoAlation protects against ROS-induced cellular damage, and how this in turn influences healthy cell/tissue function throughout life. This project will define the precise role of CoA in the regulation of the membrane-repair function of PRDX6, thereby establishing a new antioxidant defense mechanism that could be targeted to promote healthy ageing.
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