Investigating the role of coenzyme A in peroxiredoxin 6 mediated oxidative stress resistance, membrane integrity and healthy ageing.

Ivan Gout (primary)
Structural and Molecular Biology
University College London
John Labbadia (secondary)
Institute of Healthy Ageing
University College London


Maintaining redox homeostasis is crucial for cell viability. It has recently been discovered that coenzyme A (CoA) acts as an essential antioxidant, protecting cells against oxidative stress and iron-induced cell death (ferroptosis). These effects are mediated through CoA-dependent regulation of peroxiredoxin-6 (CoAlation). However, it remains unknown exactly how PRDX6 CoAlation protects against ROS-induced cellular damage, and how this in turn influences healthy cell/tissue function throughout life. This project will define the precise role of CoA in the regulation of the membrane-repair function of PRDX6, thereby establishing a new antioxidant defense mechanism that could be targeted to promote healthy ageing.


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Molecules, cells and industrial biotechnology
Area of Biology
AgeingCell Biology
Techniques & Approaches
BiochemistryBiophysicsGeneticsImage ProcessingMicroscopy / ElectrophysiologyMolecular Biology