Investigation of the protective role of anti-PfGARP antibodies against severe malaria

Samuel Crocodile Wassmer (primary)
Infection Biology
London School of Hygiene & Tropical Medicine
Kevin Tetteh (secondary)
Infection Biology


Malaria caused by Plasmodium falciparum remains a leading cause of mortality in endemic areas and factors that influence the outcome of an infection remain unknown, impeding the development of an effective vaccine. We aim to combine our joint expertise on severe malaria pathogenesis and serology screening to assess the role of parasite antigen P. falciparum glutamic-acid-rich protein (PfGARP) in the development of immune protection from severe disease.


Wassmer SC, Taylor TE, Rathod PK, Mishra SK, Mohanty S, Arevalo-Herrera M, Duraisingh MT, Smith JD. Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach. Am J Trop Med Hyg. 2015 Sep;93(3 Suppl):42-56. doi: 10.4269/ajtmh.14-0841.

Wu L, Hall T, Ssewanyana I, Oulton T, Patterson C, Vasileva H, Singh S, Affara M, Mwesigwa J, Correa S, Bah M, D’Alessandro U, SepĂșlveda N, Drakeley C, Tetteh KKA. Optimisation and standardisation of a multiplex immunoassay of diverse Plasmodium falciparum antigens to assess changes in malaria transmission using sero-epidemiology. Wellcome Open Res. April 2020. DOI: 10.12688/wellcomeopenres.14950.2

Raj DK, Mohapatra AD, Jnawali A, et al. Anti-PfGARP activates programmed cell death of parasites and reduces severe malaria. Nature, ePub April 2020.

Uplekar S, Rao PN, Ramanathapuram L, Awasthi V, Verma K, Sutton P, Ali SZ, Patel A, G SL, Ravishankaran S, Desai N, Tandel N, Choubey S, Barla P, Kanagaraj D, Eapen A, Pradhan K, Singh R, Jain A, Felgner PL, Davies DH, Carlton JM, Das J. Characterizing Antibody Responses to Plasmodium vivax and Plasmodium falciparum Antigens in India Using Genome-Scale Protein Microarrays. PLoS Negl Trop Dis. 2017 Jan 24;11(1):e0005323. doi: 10.1371/journal.pntd.0005323.

van den Hoogen LL, Walk J, Oulton T, Reuling IJ, Reiling L, Beeson JG, Coppel RL, Singh SK, Draper SJ, Bousema T, Drakeley C, Sauerwein R, Tetteh KKA. Antibody Responses to Antigenic Targets of Recent Exposure Are Associated With Low-Density Parasitemia in Controlled Human Plasmodium falciparum Infections. Front Microbiol. 2019 Jan 16;9:3300. doi: 10.3389/fmicb.2018.03300. eCollection 2018. PMID: 30700984

Molecules, cells and industrial biotechnology
Area of Biology
Techniques & Approaches
BiochemistryBioinformaticsBiophysicsMathematics / StatisticsMolecular Biology