Abstract
Tight homeostatic control of the essential trace metals, manganese and iron, is crucial for normal brain physiology. Both manganese and iron are required for neuronal processes including myelination, synaptogenesis, and synaptic plasticity. However, excess or deficiency of either metal are detrimental to neuronal integrity. Trafficking and metabolism of these two metals are closely interlinked but little is known about how their interactions can modulate neuronal function under normal physiological conditions and in ageing. This project aims to elucidate the interplay between manganese and iron within neuronal circuits using zebrafish and neuronal cell models of metal dyshomeostasis.
References
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