Stratification is a tissue organisation that is particularly well-suited for organs that are exposed to abrasive elements, and pathogens. In these tissues, stem cells that are located in the basal cell-layer generate new cells to constantly renew the supra-basal, surface layers. This tissue maintenance process requires cells to i) leave the basal layer, and ii) migrate towards the surface of the tissue. We know little about the cell biology that underpins these essential steps of tissue maintenance. This is what the student will study here by combining a novel gene discovery approach in vivo, and mathematical modelling in silico.
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