Abstract
Our understanding of the interplay between mechanics and biology, i.e. mechanobiology, of calvarial healing is limited. Mouse is an excellent model to study the calvarial healing due to its close genetic and morphological similarities to human. Our previous work has shown that calvarial defects in mouse show site specific healing pattern e.g. defects in the frontal bones heal faster than the parietal bones. This might be due to differences in the cellular origins of frontal (neural crest) and parietal (mesoderm). However, the mechanical loading experienced in these regions can also be vastly different and crucial to our observations. The overall aim of this project is to advance our understanding of the mechanobiology of calvarial healing using a series of in vivo, ex vivo experiments, imaging and computational modelling techniques.
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