Metabolic biomarkers and pathways of ageing in rural India

Sanjay Kinra (primary)
Department of Non-communicable disease epidemiology
London School of Hygiene and Tropical Medicine
Cristina Legido-Quigley (secondary)
Institute of Pharmaceutical Sciences
KCL / Steno Diabetes Centre


This PhD project aims to identify plasma metabolite markers of accelerated phenotypic ageing in a rural Indian population experiencing social transition. The successful candidate will work with an interdisciplinary supervisory team of clinical epidemiologist and analytical chemist to establish ageing phenotypes in this population, identify known and novel metabolites, and perform data driven and systems/pathway analyses of dysregulated metabolites in the ageing process. The data source for this project will be APCAPS (, an ongoing longitudinal, population-based study of ~6000 adults living in rural and peri-urban Telangana, South India.


1 Kinra S, et al. Cohort profile: Andhra Pradesh Children and Parents Study (APCAPS). Int J Epidemiol. 2014 Oct;43(5):1417-24. doi: 10.1093/ije/dyt128. Epub 2013 Sep 9. PMID: 24019421; PMCID: PMC4190511
2 Mei Sum Chan, et al. A Biomarker-based Biological Age in UK Biobank: Composition and Prediction of Mortality and Hospital Admissions, The Journals of Gerontology: Series A, 2021;, glab069,
3 Srivastava S. Emerging Insights into the Metabolic Alterations in Aging Using Metabolomics. Metabolites. 2019;9(12):301. Published 2019 Dec 13. doi:10.3390/metabo9120301
4 Menni C, et al, Metabolomic markers reveal novel pathways of ageing and early development in human populations, International Journal of Epidemiology, Volume 42, Issue 4, August 2013, Pages 1111–1119,

Molecules, cells and industrial biotechnology
Area of Biology
AgeingChemical Biology
Techniques & Approaches
BioinformaticsChemistryMathematics / Statistics