Minimal molecular switches and clocks

Attila Csikász-Nagy (primary)
Randall Division of Cell and Molecular Biophysics
King's College London
Chris Barnes (secondary)
Cell & Developmental Biology
University College London

Abstract

Biological regulatory networks contain several feedback and feed-forward loops controlling their dynamical behaviour. We just started to understand how regulatory modules of such networks can induce oscillations or create alternative steady states. Still, we do not really understand them until we cannot build such systems. We use mathematical modelling to design minimalistic regulatory networks that can drive both oscillations and biological switches. This will help us to come up with theories on the evolution of minimal biological regulatory networks and at the same time our results could be used to design more complex synthetic regulatory networks with various biological functions.


References

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2. Cardelli L, Hernansaiz-Ballesteros RD, Dalchau N, Csikász-Nagy A. (2017) Efficient Switches in Biology and Computer Science. PLoS Comput Biol 13(1):e1005100

3. Csikasz-Nagy A, Battogtokh D, Chen KC, Novák B & Tyson JJ. (2006) Analysis of a generic model of eukaryotic cell cycle regulation. Biophys J 90, 4361-4379

4. Woods, M., Leon, M., Perez-Carrasco, R. & Barnes, C.P. (2016) A statistical approach reveals designs for the most robust stochastic gene oscillators. ACS Synthetic Biology

5. (6), pp 459–470 5 Leon, M., Woods, M.L., Fedorec, A.J.H., & Barnes, C.P. (2016) A computational method for the investigation of multistable systems and its application to genetic switches. BMC Systems Biology


BBSRC Area
Genes, development and STEM* approaches to biology
Area of Biology
BiotechnologyGenetics
Techniques & Approaches
BioinformaticsEngineeringGeneticsMathematics / StatisticsMicroscopy / ElectrophysiologyMolecular BiologySimulation / Modelling