Serotonin is a vital component of the human nervous system with the neurotransmitter playing a variety of roles in physiology including sensory perception, mood, cognition and memory. Perturbation of the serotonergic system is implicated in anxiety disorders and serotonin transporters are notable drug targets for antidepressants and antipsychotics. This project aims to increase molecular-level understanding of these neurotransmitter transporters through structure and function study. Cryo-electron microscopy, cryo-EM, will be undertaken on the human serotonin transporter in lipid nanodiscs following direct extraction from the membrane using a novel polymer, DIBMA, method.
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