Molecular zinc/iron interaction: understanding structure and function of zinc transporters

Surjit Kaila Srai (primary)
Structural and Molecular Biology
University College London
Wolfgang Maret (secondary)
Diabetes and Nutritional Sciences
University College London

Abstract

Zip 8 (zinc transporter gene SLC 39A8) is a promiscuous metal transporter of a family or 14 proteins in humans, mutations in which have been implicated in human diseases such as diabetes, osteoarthritis and autosomal-recessive intellectual disability).  In this study we will determine the transport characteristics of Zip 8 using Xenopus laevis oocytes, and determine its trafficking from the plasma membrane to intracellular compartments, and its interaction with the retromer complex using cellular, molecular, transport and chemical techniques. Bioinformatics will be used to relate structure and function.


References

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BBSRC Area
Molecules, cells and industrial biotechnology
Area of Biology
Cell BiologyChemical Biology
Techniques & Approaches
BiochemistryBioinformaticsChemistryMicroscopy / ElectrophysiologyMolecular Biology