Abstract
Zip 8 (zinc transporter gene SLC 39A8) is a promiscuous metal transporter of a family or 14 proteins in humans, mutations in which have been implicated in human diseases such as diabetes, osteoarthritis and autosomal-recessive intellectual disability). In this study we will determine the transport characteristics of Zip 8 using Xenopus laevis oocytes, and determine its trafficking from the plasma membrane to intracellular compartments, and its interaction with the retromer complex using cellular, molecular, transport and chemical techniques. Bioinformatics will be used to relate structure and function.
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