Monitoring CNS oxygenation and mitochondrial function during the development and resolution of a neuroinflammatory model of multiple sclerosis

Kenneth Smith (primary)
UCL Institute of Neurology, Neuroinflammation
UCL Institute of Neurology
Ilias Tachtsidis (secondary)
Medical Physics
University College London

Abstract

Mitochondrial dysfunction and tissue hypoxia are major contributors to neuroinflammatory and neurodegenerative disease, but research into novel therapies is hampered because these pathologies are largely invisible to most imaging techniques. This limitation can be overcome by advances in near infrared spectroscopy (NIRS) which allow mitochondrial function, blood haemodynamics and oxygenation to be assessed in vivo, thereby illuminating (literally!) how energy dysfunction contributes to neurological damage. Our goal is to create novel protocols for multispectral imaging, and then to apply them to animal models of ageing and neuroinflammatory disease to explore the efficacy of new neuroprotective strategies.


References

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BBSRC Area
Animal disease, health and welfare
Area of Biology
BiotechnologyNeurobiology
Techniques & Approaches
BiophysicsEngineeringMathematics / StatisticsMicroscopy / ElectrophysiologySimulation / Modelling