Abstract
Several proteins that interact with androgen-receptor are upregulated in diseases such as pulmonary and liver fibrosis. Combining the patient access and cell biology expertise of the Porter lab with the biophysics and structural biology skills of the Isaacson lab, this project seeks to characterise and explore the structure-function relationship between these interacting proteins and gain a unique perspective on their role in disease with a view to novel therapeutic design.
References
Mikkonen, Laura., et al. Androgen receptor and androgen-dependent gene expression in lung. Mol. Cell. Endocrinol. 317, 14–24 (2010)
Porter Joanna C and Alan Hall. Epithelial ICAM-1 and ICAM-2 regulate the egression of human T cells across the bronchial epithelium. FASEB J. 23, 492-502 (2009)
Roberts, Joanna D., et al. Structural and functional insights into small, glutamine-rich, tetratricopeptide repeat protein alpha. Frontiers in molecular biosciences 2 (2015).
Krysztofinska, E.M. et al. Structural and functional insights into the E3 ligase, RNF126. Sci. Rep. 6, 26433. (2016)
Khawaja, Akif. A., Pericleous, C., Thomas, L. W., Ashcroft, M., Giles, I. & Porter, J. C. Hypoxia increase neutrophil extracellular trap formation and adhesion to endothelial cells. Rheumatology, 54, 41-42. (2015)