Abstract
Several proteins that interact with androgen-receptor are up-regulated in diseases such as pulmonary and liver fibrosis. Combining the patient access and cell biology expertise of the Porter lab with the biophysics and structural biology skills of the Isaacson lab, this project seeks to characterise and explore the structure-function relationship between these interacting proteins and gain a unique perspective on their role in disease with a view to novel therapeutic design.
References
1 Mikkonen, Laura., et al. Androgen receptor and androgen-dependent gene expression in lung. Mol. Cell. Endocrinol. 317, 14–24 (2010)
2 Porter Joanna C and Alan Hall. Epithelial ICAM-1 and ICAM-2 regulate the egression of human T cells across the bronchial epithelium. FASEB J. 23, 492-502 (2009)
3 Roberts, Joanna D., et al. Structural and functional insights into small, glutamine-rich, tetratricopeptide repeat protein alpha. Frontiers in molecular biosciences 2 (2015).
4 Martínez-Lumbreras, S. et al. Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control. BMC Biology 16(1):76 (2018)
5 Khawaja AK, Chong DLW, Sahota J, Pericleous C, Ripoli VM, Booth HL, Khan S, Rodriguez-Justo M, Giles IP, Porter JC Identification of a novel HIF-1α-αMβ2 Integrin-NETosis axis in fibrotic interstitial lung disease. Frontiers in Immunology; 2020