Abstract
Spatial audiovisual integration is a critical ability, whether prey, predator, or pedestrian crossing the street. However, immersive audiovisual environments remain unstudied, at least in part because colocalizing visual and auditory stimuli throughout space is technologically challenging. We have developed the first audiovisual dome, where visual and auditory stimuli can be colocalized throughout space while head-fixed mice navigate an audiovisual environment. While mice navigate, we propose to record activity in key brain regions with chronically implanted Neuropixels 2.0 probes and determine how auditory and visual navigation signals are combined in the brain.
References
1. Philip Coen, Timothy P.H. Sit, Miles J Wells, Matteo Carandini, Kenneth D Harris. Mouse frontal cortex mediates additive multisensory decisions bioRxiv 2021.04.26.441250
2. Saleem, A.B., Diamanti, E.M., Fournier, J. et al. Coherent encoding of subjective spatial position in visual cortex and hippocampus. Nature 562, 124–127 (2018).
3. Aronov, D., Nevers, R. & Tank, D. Mapping of a non-spatial dimension by the hippocampal–entorhinal circuit. Nature 543, 719–722 (2017).
4. Runyan, C., Piasini, E., Panzeri, S. et al. Distinct timescales of population coding across cortex. Nature 548, 92–96 (2017).
5. Krumin, M. Julie J Lee, Kenneth D Harris, Matteo Carandini. Decision and navigation in mouse parietal cortex. Elife 7, e42583 (2018).