Neural mechanisms for dynamic modulation of protective reflexes

Liam Browne (primary)
Wolfson Institute for Biomedical Research
University College London
Andrew Murray (secondary)
Sainsbury-Wellcome Centre
University College London

Abstract

Potentially harmful stimuli are detected at the skin by nociceptor sensory neurons that drive rapid protective withdrawal reflexes. These protective responses act to quickly remove the affected limb from a source of danger, but without compromising balance and increasing further risk of harm. Here we set out to define the relationship between simplistic motor reflexes and feedback from postural systems. We hypothesise that specific connectivity exists between postural systems in the brain and nociceptive spinal cord neurons, that dynamically modulate the timing and nature of these reflexes to embed them within more complex protective behaviours.


References

Browne LE, Latremoliere A, Lehnert BP, Grantham A, Ward C, Alexandre C, Costigan M, Michoud F, Roberson DP, Ginty DD, Woolf CJ. Time-resolved fast mammalian behavior reveals complexity of protective pain responses. Cell Reports. 20, 89-98 (2017)

Murray AJ, Croce K, Belton T, Akay T, Jessell TM Balance Control Mediated by Vestibular Circuits Directing Limb Extension or Antagonist Muscle Co-activation. Cell Reports. 22, 1325-1388 (2018)

Reardon TR*, Murray AJ*, Turi GF, Wirblich C, Croce KR, Schnell MJ, Jessell TM, Losonczy A (2016) Rabies Virus CVS-N2cΔG Strain Enhances Retrograde Synaptic Transfer and Neuronal Viability. Neuron 89, 711-724.


BBSRC Area
Genes, development and STEM* approaches to biology
Area of Biology
NeurobiologyPhysiology
Techniques & Approaches
GeneticsImage ProcessingMathematics / StatisticsMicroscopy / ElectrophysiologyMolecular Biology