Abstract
Healthy older adults show wide variation in cognitive performance that does not relate directly to measures of underlying neuropathological burden. Iron-mediated oxidative stress is a potential mechanism for the neuronal vulnerability in healthy ageing. MRI Quantitative Susceptibility Mapping (QSM) measures tissue composition and is dominated by iron content in the brain. This project will use QSM to measure brain iron changes in healthy older individuals and investigate the relationship between these and performance across cognitive domains at baseline and after longitudinal follow-up. This will provide new and important insights into the neural substrates of early cognitive changes in healthy ageing.
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