Next generation, immunocompetent 3D tissue models of cancer for testing targeted nanotechnology

Marilena Loizidou (primary)
Division of Surgery and Interventional Science
David Abraham (secondary)
Division of Medicine


We will develop tissue-engineered complex model systems in 3D, which contain distinct cell
populations, modelling complex tissues. We will use these to evaluate action of nanotargeted
agents directed against critical pathways controlling cell growth and proliferation.
Incorporating immune cells is the key innovation for this model. Cancer progression within
the complex milieu will be interrogated at the tissue, cell and genetic level. New generation
biologics, acting directly against cancer cells and indirectly by recruiting immune cells, will be
tested in immunocompetent models. Novel biologic-nanoparticle conjugates serving as dual
imaging/therapeutic agents will map drug-cell interactions and drug fate within tissues.


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Genes, development and STEM* approaches to biology
Area of Biology
Techniques & Approaches
BiochemistryChemistryEngineeringMicroscopy / ElectrophysiologyMolecular Biology