Abstract
In recent years, cell delivery using biomaterials has been used to grow new blood vessels and promote regeneration. In a previous study, we found that the administration of biomaterials alone attracted macrophages and enhanced vascularisation of ischaemic tissue. In this project, we propose to investigate the role of macrophages and their behaviour/polarisation in response to their interaction with different types of TIPS biomaterials with the overarching aim of promoting angiogenesis and regeneration.
References
1 Hendow E, Iacoviello F, Casajuana M, Pellet-Many C, Day R 2020 Microporous Biodegradable Films Promote Therapeutic Angiogenesis. Adv. Healthcare Mater. 9 17, 2070059.
2 Krishnasamy K, Limbourg A, Kapanadze T, Gamrekelashvili J, Beger C, Hager C, Lozanovski VJ, Falk CS, Napp LC, Bauersachs J, Mack M, Haller H, Weber C, Adams RH, Limbourg FP 2017 Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia. Nat Commun 8 1:952.
3 Hsieh PL, Rybalko V, Baker AB, Suggs LJ, Farrar RP 2018 Recruitment and therapeutic application of macrophages in skeletal muscles after hind limb ischemia. J Vasc Surg 67 6:1908-1920 e1901.
4 Sridharan R, Cameron AR, Kelly DJ, Kearney CJ, O’Brien FJ 2015 Biomaterial based modulation of macrophage polarization: a review and suggested design principles. Materials Today 18 6: 313-325.