Optimising Angiogenesis: How Thermally Induced Phase Separation TIPS-based biomaterials influence macrophage cell behaviour?

Caroline Pellet-Many      (primary)
Comparative Biomedical Sciences
Royal Veterinary College
Richard Day     (secondary)
Division of Medicine
University College London


In recent years, cell delivery using biomaterials has been used to grow new blood vessels and promote regeneration. In a previous study, we found that the administration of biomaterials alone attracted macrophages and enhanced vascularisation of ischaemic tissue. In this project, we propose to investigate the role of macrophages and their behaviour/polarisation in response to their interaction with different types of TIPS biomaterials with the overarching aim of promoting angiogenesis and regeneration.


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