Abstract
Proteins require a correct structural fold for their functionality, and consequently many diseases originate from the failure of proteins to fold productively in the cell. Folding begins co-translationally when the emerging polypeptide is still attached to its parent ribosome, and this project aims to probe the co-translational folding of polypeptides during synthesis with an emphasis on how the ribosome’s structure and chemical properties modulate this fundamental process.
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