Protein Folding on the Ribosome: probing the ribosomal machinery during biosynthesis at high resolution.

John Christodoulou (primary)
Institute of Structural and Molecular Biology
UCL and Birkbeck College
Lisa Cabrita (secondary)
Institute of Structural and Molecular Biology


Proteins require a correct structural fold for their functionality, and consequently many diseases originate from the failure of proteins to fold productively in the cell. Folding begins co-translationally when the emerging polypeptide is still attached to its parent ribosome, and this project aims to probe the co-translational folding of polypeptides during synthesis with an emphasis on how the ribosome’s structure and chemical properties modulate this fundamental process.


[1] Cabrita et al. (2016) Nat Struct Mol Biol 23, 278-285
[2] Deckert et al. (2016) PNAS 113 (18), 5012-5017
[3] Waudby et al. (2018) PNAS 115 (39), 9744-9749
[4] Kudva et al. (2018) eLife 7, e36326
[5] Contreras-Martinez et al. (2012) Biotechnol J, 7 (3), 354-360

Molecules, cells and industrial biotechnology
Area of Biology
Structural Biology
Techniques & Approaches
BiochemistryBioinformaticsBiophysicsChemistryImage ProcessingMicroscopy / ElectrophysiologyMolecular BiologySimulation / Modelling