Abstract
Sclerostin is a potent WNT inhibitor that has been shown to protect cartilage from injury and encourage cartilage formation from cells. The therapeutic use of sclerostin is restricted by its short half-life and a limited capacity to target its effects to cartilage. With this project we propose the generation of a sclerostin mimetic, which is stabilised and targeted to cartilage cells. This will be tested for its regenerative efficacy in models of cartilage healing and cartilage formation. We will also define the molecular mechanism underpinning the homeostatic effect of sclerostin in cartilage.
References
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