Regenerating the kidney by restoring the renal microvasculature

David Long (primary)
Institute of Child Health
University College London
Dr Tammy Kalber (secondary)
Department of Imaging, Division of Medicine
University College London


The small vessels within the kidney become damaged in patients with renal disease. This project will attempt to
use cells to restore the damaged kidney blood vessels which we predict will then lead to regeneration of the
diseased kidney. We will test different sources of cells, administration routes and timing of treatment to
determine the optimal therapy to improve kidney disease. If successful, these studies could potentially lead to
clinical trials using cell-based therapies for renal regeneration and repair.


1 Long DA et al. Nat Rev Nephrol 8: 244-250, 2012.
2 Long et al Kidney Int 74: 300-309, 2008.
3 Ogunlade O et al Am J Physiol Renal Physiol 314: F1145-F1153, 2018
4 Papakrivopoulou et al J Pathol doi: 10.1002/path.5158. [Epub ahead of print], 2018.
5 Huang et al J Am Soc Nephrol 27: 69-77, 2016.

Molecules, cells and industrial biotechnology
Area of Biology
Cell BiologyPhysiology
Techniques & Approaches
BiophysicsEngineeringImage ProcessingMicroscopy / ElectrophysiologyMolecular Biology