Regulation of the growth-modulating functions of the atypical cadherin Fat

Paulo Ribeiro (primary)
Barts Cancer Institute
Queen Mary University of London
Nicolas Tapon (secondary)
Apoptosis and Proliferation Control Laboratory
The Francis Crick Institute / UCL


How tissue growth is mechanistically controlled remains poorly understood. The atypical cadherin Fat regulates the growth-controlling Hippo signalling pathway via various effector proteins and mechanisms, which remain poorly characterised. We recently found that Fat is regulated by a deubiquitylating enzyme, suggesting that reversible ubiquitylation impacts on the role of Fat in Hippo signalling and tissue growth. We aim to define the molecular mechanisms that regulate Fat and to explore the role of ubiquitylation in modulating Fat function in tissue growth control. We hypothesise that reversible ubiquitylation is key for this process and propose to elucidate the underlying molecular mechanisms.


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