Regulation of the septin cytoskeleton during cell division

Ulrike Eggert (primary)
Randall Division/Chemistry
Guillaume Charras (secondary)
London Centre for Nanotechnology


Septins are a family of filamentous proteins that are part of the cytoskeleton. They link the cytoskeleton to the plasma membrane and mediate many processes, including cell division. Many aspects of septin biology are poorly understood. We have discovered a regulator of septins during cell division (called CDC42EP1), which allows us to perturb septins and therefore to study their functions. This project will use interdisciplinary approaches to gain new insights into how septins participate in cell division.


Membrane and organelle dynamics during cell division. J.G. Carlton, H. Jones, U.S. Eggert,, Nature Rev Mol Cell Biol, 21, 151 (2020)

Capping protein regulates actin dynamics during cytokinetic midbody maturation. S.J. Terry, F. Donà, P. Osenberg, J.G. Carlton, U.S. Eggert, Proc Natl Acad Sci USA 115, 2143 (2018)

Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts.
Calvo F, Ranftl R, Hooper S, Farrugia AJ, Moeendarbary E, Bruckbauer A, Batista F, Charras G, Sahai E. Cell Rep. Dec 29;13(12):2699-714 (2015)

Cao L, Yonis A, Vaghela M, …, Romet-Lemonne G, Charras G. “SPIN90 associates with mDia1 and the Arp2/3 complex to control cortical actin organization”. Nature Cell Biology, 22:803-814, (2020).

Kelkar M, Bohec P, Charras G. “Mechanics of the cellular actin cortex: from signalling to shape change”, Current Opinion in Cell Biology, 66:69-78, (2020).

Molecules, cells and industrial biotechnology
Area of Biology
Cell BiologyChemical Biology
Techniques & Approaches
BiochemistryBiophysicsMicroscopy / Electrophysiology