Septins are a family of filamentous proteins that are part of the cytoskeleton. They link the cytoskeleton to the plasma membrane and mediate many processes, including cell division. Many aspects of septin biology are poorly understood. We have discovered a regulator of septins during cell division (called CDC42EP1), which allows us to perturb septins and therefore to study their functions. This project will use interdisciplinary approaches to gain new insights into how septins participate in cell division.
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Capping protein regulates actin dynamics during cytokinetic midbody maturation. S.J. Terry, F. Donà, P. Osenberg, J.G. Carlton, U.S. Eggert, Proc Natl Acad Sci USA 115, 2143 (2018)
Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts.
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