Mitochondria are key hubs of cellular redox metabolism, enabling electron flow through the citric acid cycle to the respiratory chain and oxygen as final electron acceptor. Not surprisingly, a large gene network, composed of (i) a significant proportion (>5%) of the nuclear genome and (ii) the small but essential mitochondrial genome, underlies the maintenance of cellular redox balance. The project will focus on understanding the remodeling of the metabolic gene network in response to alterations in the mitochondrial genome and evaluate the functional consequences on metabolic fluxes in central carbon metabolism, by applying transcriptome and metabolic flux analysis and modelling.
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Kiparissides, A., Hatzimanikatis V. (2017). Thermodynamics-based Metabolite Sensitivity Analysis in Metabolic Networks. Metabolic Engineering, v.39, pp: 117-127