Energy metabolism is fundamental to life. We want to understand how energy metabolism adapts to different lifestyles, and how its key processes can be altered. We work with two species of yeast that differ in their energy metabolism, with one yeast being capable of growing without respiration and oxygen. The student will 1) dissect the genetic and physiological characteristics determining these striking metabolic differences, and 2) genetically edit yeast cells in order to rewire their energy metabolism. This research will provide unique insights into metabolic changes occurring during ageing and associated diseases as well as potential biotechnological applications.
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Makarova, M, Peter, M., Balogh, G., Glatz, A., MacRae, J., Lopez Mora, N., Booth, P., Makeyev, E., Vigh, L. and S. Oliferenko. 2020. Delineating the rules for structural adaptation of membrane-associated proteins to evolutionary changes in membrane lipidome. Current Biology. 30:367-380
Jeffares DC, Rallis C, Rieux A, Speed D, …., Bähler J. 2015. The genomic and phenotypic diversity of Schizosaccharomyces pombe. Nature Genetics. 47:235-241
Malecki M, Bitton DA, Rodríguez-López M, Rallis C, Garcia Calavia N, Smith GC, Bähler J (2016). Functional and regulatory profiling of energy metabolism in fission yeast. Genome Biology 17:240
Pieper, G., Sprenger, S., Teis, D. and S. Oliferenko. 2020. ESCRT-III/Vps4 controls heterochromatin-nuclear envelope attachments. Developmental Cell 53:27-41