Role for the cross-talk between focal adhesion-TGF beta signalling in activating cellular senescence and ageing

Abstract

Cellular senescence is a process by which primary cells detect a stress signal, stop replicating and modify their surrounding microenvironment^1,2. The accumulation of senescent cells contributes to organismal ageing³, but the precise mechanisms regulating this process are not well understood. Our lab has recently described the need for the interaction of focal adhesion (FA) with the extracellular matrix (ECM) regulating senescence and ageing, by activating the TGFb pathway⁴. However, the mechanisms implicated, the impact throughout ageing and the discovery of therapeutic targets to tackle senescent cells regulating FA, have not been addressed.

References

1. Acosta, J.C., O’Loghlen A. et al. (2008) Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell 133, 1006–1018
2. Muñoz-Espín, D. and Serrano, M. (2014) Cellular senescence: from physiology to pathology. Nat. Rev. Mol. Cell Biol. 15, 482–96
3. Baker, D.J. et al. (2016) Naturally occurring p16Ink4a-positive cells shorten healthy lifespan. Nature DOI: 10.1038/nature16932
4. Rapisarda et al. (2016) Integrin beta 3 regulates cellular senescence and ageing. Submitted to Cell Reports
5. Hosny, N.A. et al. (2013) Super-Resolution Imaging Strategies for Cell Biologists Using a Spinning Disk Microscope. PLoS One 8,