Abstract
Long considered an inert temporary container for the viral genome, the capsid of HIV is increasingly emerging as a major determinant of infection dynamics. Through its interactions with host factors and its control of reverse transcription, it fulfills an essential role as a ‘cloaking device’, preventing the host from sensing the virus until the infection has been established. We are investigating the role and mechanisms of interaction between the capsid and host using a combination of phylogenetic, biochemical and structural biological approaches.
References
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