The role of the somatosensory cortex in nociception

Liam Browne (primary)
Wolfson Institute for Biomedical Research
University College London
Matteo Carandini (secondary)
Institute of Ophthalmology
University College London

Abstract

Potentially harmful stimuli are detected at the skin by nociceptor sensory neurons that drive rapid protective withdrawal behaviours. It is unclear how the somatosensory system encodes and integrates information from stimuli causing pain. Here we will use a number of advanced technologies to understand the role of the somatosensory cortex in encoding and integrating nociceptive information to coordinate appropriate protective responses to noxious stimuli. This should provide exciting new insights into how the nervous system guides behavioural responses to minimise risk of harm.


References

  1. Browne LE1, Latremoliere A, Lehnert BP, Grantham A, Ward C, Alexandre C, Costigan M, Michoud F, Roberson DP, Ginty DD, Woolf CJ. Time-resolved fast mammalian behavior reveals complexity of protective pain responses. Cell Reports, 2017 (in press). 1lead & co-corresponding author.
  2. Browne LE, Woolf CJ. Casting light on pain. Nature Biotechnology, 2014, 32, 240-1.
  3. Carandini M, Shimaoka D, Rossi LF, Sato TK, Benucci A, Knöpfel T. Imaging the awake visual cortex with a genetically encoded voltage indicator. Journal of Neuroscience. 2015 35, 53-63.
  4. Haider B, Schulz DP, Häusser M, Carandini M. Millisecond Coupling of Local Field Potentials to Synaptic Currents in the Awake Visual Cortex. Neuron. 2016, 90, 35-42.
  5. Browne LE, Nunes J, Sim J, Chudasama V, Bragg L, Caddick S and North RA. Optical control of trimeric P2X receptors and acid-sensing ion channels. PNAS, 2014, 111, 521-526.

BBSRC Area
Genes, development and STEM* approaches to biology
Area of Biology
GeneticsNeurobiologyPhysiology
Techniques & Approaches
EngineeringGeneticsImage ProcessingMathematics / StatisticsMicroscopy / ElectrophysiologyMolecular Biology