Abstract
Embryonic development is a wonder of biology. The differentiation of thousands of cells must be organised in space and time. How robust and reproducible cell differentiation is coordinated remains a fundamental question.
The advent of ‘single cell genomics’ offers an unprecedented opportunity to address this question. It allows gene networks controlling differentiation to be determined and gene expression to be followed as cells transition from pluripotent to differentiated states.
Your goal will be to develop computational methods to interpret this revolutionary data, design a novel theoretical framework for understanding differentiation and experimentally test these ideas in the lab.
References
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