Abstract
The actomyosin cytoskeleton is a main regulator of cell shapes in developing epithelia. The aim of this project is to understand how this cellular contractile machinery is integrated at the tissue level to generate complex organs. This aim will be achieved by using a combination of live-cell imaging, computer simulations, and state-of-the-art quantitative approaches. Experimental approaches will use live super resolution imaging of the actomyosin cytoskeleton during multicellular patterning, optogenetics and mechanical experiments designed at perturbating the contractility of actomyosin meshworks. Together, these approaches will examine how the dynamics of the actomyosin contractile machinery enables complex tissue patterning during development.
References
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